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Antipsychotic–benzodiazepine combinations might be among the most effective options for rapid tranquilisation in patients with psychomotor agitation but carry a risk of hypotension, whereas haloperidol monotherapy appeared among the least effective and is associated with extrapyramidal side-effects. These findings should be contextualised to the specific setting and patient char...

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Agitation accounts for 10–25% of emergency psychiatric presentations.1–4 Managing agitation is challenging due to its high prevalence, complexity, multifactorial origins, and poor treatment resources. Prompt and effective treatment of agitation is needed to prevent escalation to aggression or violence, and reduce the associated adverse patient, family, and health-care outcomes. ...

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Our findings challenge both therapeutic inertia—accepting suboptimal response without further dose titration—and uncritical dose escalation beyond licensed limits, when potential harms outweigh expected benefits. Our findings can inform clinical guidelines and should support shared decision making regarding ADHD medication dosage.

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This systematic review and meta-analysis indicated a small association between antidepressants and ADHD or ASD, which was attenuated or became non-significant after adjusting for confounding factors. Antidepressant treatment should be continued for pregnant women with moderate-to-severe depression. Optimising both maternal and paternal mental health is essential for the child's ...

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Brand BA, Behrman S, Marwick KFM, et al. Women and psychosis: a guide to evidence-based, hormone-informed care. Lancet Psychiatry 2026; 13: 508–21—In this Review, Iris E C Sommer has been added as an author. This correction has been made to the online version as of May 14, 2026, and the printed version is correct.

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