The Evidence Based Rheumatology Podcast

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Message History

E134: Brepocitinib in Dermatomyositis (VALOR)2 days

Great trial this week looking at brepocitinib in dermatomyositis. Looks like a winner, expect it will be approved. Where it fits in our approach to IIM is an open question, but nice to have another option.

Study: https://www.nejm.org/doi/10.1056/NEJMoa2503531<...

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E133: Obinutuzumab for SLE (ALLEGORY)1 month

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E132: Romosozumab vs teriparatide for osteoproosis (STRUCTURE)2 months

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E131: A Sham-Controlled Sham of a Trial: RESET-RA3 months

Today I cover the recent publication of the RESET-RA study, which evaluated vagal nerve stimulation to treat rheumatoid arthritis. Have a listen in full, but let me be clear upfront: I do not think this works and will not be referring any patients to receive it. This will forever be my pivotal example of the effect of unblinding, but would love to hear if you think different!...

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E130: Telitacicept for SLE4 months

Surprisingly (unbelievably?) impressive RCT evaluating the Blys/APRIL inhibitor "telitacicept" for patients with SLE (mixed SLE and SLE-LN). Very curious to see where the FDA goes with this one.

Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2414719

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