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Nucleic Acid Therapeutics Toolbox: Targeted delivery with lipophilic modifiers

Nucleic acid therapeutics have the potential to treat a range of diseases but getting them where they are needed in the body remains one of the biggest hurdles.


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How to maximise siRNA synthesis yield and be more environmentally friendly

The scope and demand for nucleic acid therapeutics is growing rapidl...


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Know Your Oligo Mod: 5' and 3' phosphate groups

Phosphate groups are one of the most popular modifications for our custom oligos. In this Know Your Oligo Mod blog post, we’ll explore how adding phosphates to either end of the oligonucleotide can dramatically alter its beh...


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How CRISPR screening tools have advanced with Endura competent cells

Jennifer Doudna, co-inventor of CRISPR-Cas9 gene editing, had a recurring dream of a tsunami approaching her on a beach. In her mind, that wave represented the powerful transformation that the technology would bring. ...


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PCR assay design, simplified: qPCR, SNP genotyping and gene expression

Design is the foundation for PCR success. Get the primers and probes right, and you’ll be set up for on-target amplification, reliable Cq values and confident calls. Below is a practical run-through of the best pr...


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