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Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents

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In This Issue
Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026.

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Extensive heterozygosity and genetic exchange among natural populations of Leishmania species
Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026.
SignificanceHybridization is increasingly recognized as a powerful evolutionary force, yet the extent to which it impacts the population genetics ofLeishmaniaremains enigmatic. Previous work suggested thatLeishmaniapropagation is predominantly by ...

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Making invisible excited-state structures of pro-interleukin-18 visible by combining NMR and machine learning
Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026.
SignificanceIn many cases accurate models of the low energy, most populated form of a protein’s three-dimensional structure can be rapidly determined using machine learning (ML) programs, such as AlphaFold. However, biomolecular function is often ...

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The institutional dynamics of inequality for women inventors who break with conventional thinking
Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026.
SignificanceThe gender innovation gap—where women’s inventions are less likely to be patented or pursued—raises concerns about its potential to slow scientific progress. Our analysis of millions of patent applications reveals that the gender gap in ...

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Type I interferons induced upon respiratory viral infection impair lung metastatic initiation
Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026.
SignificanceThe lungs are a metastatic site for cancers such as breast cancer. In addition, the lungs are constantly exposed to viruses, such as coronavirus, respiratory syncytial virus (RSV), and influenza virus. Thus, breast cancer and respiratory virus ...

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