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Targeting proteins involved in DNA repair is a promising approach against cancer. However, finding effective small molecule inhibitors can be difficult because the protein-DNA interface tends to be very polar, with few classically ligandab...

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The list of technologies used to find and validate fragments is long, with more than a dozen in our 2024 poll. But it’s always fun to learn about new approaches. At the Novalix conference earlier this year I

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Cambridge Healthtech Institute held its annual Discovery on Target (DoT) meeting in Boston last week. Attendance may have set a record, with over 1000 participants. There were sessions on antibodies, conjugates, and radioligands, but I’ll just touch on some of the small molecule themes m...

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Without a good library, it is difficult to find a good hit, so library design is one of the most import aspects of a screening campaign. The size of a library also impacts how it can be screened. A virtual or DNA-encoded library might be billi...

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