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Earlier this year we highlighted a study that compared the affinities of kinase inhibitors for isolated proteins vs those same proteins in cells and found differences – sometimes dramatic. A new open-access

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Differential scanning fluorimetry (DSF), also known as a thermal shift assay, is one of the most common techniques for fragment screening according to the most recent methods poll on Practical Fragments. This popularity is in...

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Last month Practical Fragments wrote about make-on-demand libraries, such as those offered by Enamine. We’ve also

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We're half-way through 2026, but there are still some good events ahead. And 2027 is already starting to take shape.

September 14-16: Fragments X, RSC-BMCS Tenth Fragment-based Drug Discovery Meeting, will be held in the original Cambridge (UK). You can read my ...

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Fragment linking is a compelling approach to advancing fragments, but, as our poll from several years ago showed, it often works better in theory than practice. Also, most examples of fragment linking involve non-covalent molecules. ...

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