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PLOS Computational Biology

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by R. Dustin Schaeffer, Jimin Pei, Rui Guo, Jing Zhang, Kirill Medvedev, Qian Cong, Nick Grishin

Archaea represent one of the three domains of cellular life and yet account for fewer than 1% of experimentally determined protein structures, leaving the extent of their structural novelty unknown. Here we present a systematic domain-level classification of 124,075 proteins ...

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by Zeno Messi, Franck Raynaud, Nathan W. Goehring, Alexander B. Verkhovsky

Polarization of migrating cells involves chemical and mechanical interactions of signaling networks, cytoskeleton, plasma membrane, and substrate adhesions. Still, it is not fully understood which mechanisms and components are sufficient for symmetry breaking, and if they work independently or tog...

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by Chunyan Li, Yutong Mao, Xiao Liu, Wenrui Hao

Understanding how biological systems evolve across space and time remains a fundamental challenge, particularly when dynamic processes vary substantially across individuals. We present a personalized graph-based dynamical modeling framework for characterizing spatiotemporal biological dynamics from longitudinal multimodal i...

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by Jamie J. Alnasir


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