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by Jiazheng Quan, Xibao Zhao, Shaoying Chen, Hongrui Li, Wei Chen, Qianqian Di, Xunwei Li, Jiajing Zhao, Han Wu, Jin Chen, Yue Xiao, Zherui Wu, Weilin Chen

RIG-I and STING are critical for mediating the RIG-I and cGAS-STING signaling pathways that guard against viral infection. Here, we report that ubiquitin-specific peptidase 39 (USP39) positively regulates the RIG-I an...

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by Clayton Baker, Victor A. Ansere, Cossette I. Sanqui, Bérénice A. Benayoun

Aging has effects on the immune system that are similar in men and women, but also reshapes their immune systems in unique, sex-specific ways. These sex-specific patterns of immune aging influence disease susceptibility, vaccine effectiveness, cancer survival, and responses to pharmacological th...

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by Kaisar Ahmad Lone, Amit Mahendra Karole, Geethanjali Ravindran, Shweta Tyagi

Trimethylation of histone 3 lysine 4 (H3K4me3) is a mark of active transcription, and its regulatory role in RNA polymerase II-mediated transcription has been well-studied. However, if and how this mark regulates RNA polymerase I (RNA Pol I) is not known. Here, we used customized genome assem...

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by Sean P. Heighton, Jérôme Murienne, Mukesh Thakur, Alain Didier Missoup, Wirdateti Wirdateti, Chabi Sylvestre Djagoun, Sery Bi Gonedelé, Gabriel Ngua Ayecaba, Brice Roxan Momboua, Flobert Njiokou, Anne-Lise Chaber, Helen C. Nash, Barbora Černá Bolfíková, Sylvain Dufour, Guy T. Gembu, Ayodeji Olayemi, Jordi Salmona, Amaia Iribar, Yves Cuenot, Philippe Gaubert

Pangolins ...

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