PLOS Biology

by Brent W. Stewart, Matthew A. Cormie, Michael L. Keaser, Massieh Moayedi, Brian N. Mathur, David A. Seminowicz

Cognitive control is believed to arise from task-dependent interactions among networks of brain regions. Although several debilitating neuropsychiatric disorders are characterized by cognitive network dysfunction, the neural circuit mechanisms supporting task-...

by Anamaria Necsulea

Recombination suppression leads to genomic erosion through an accumulation of deleterious mutations. A new study in PLOS Biology reveals an outstanding increase in aberrant splicing in non-recombining genomic regions in green algae. Recombination suppression leads to genomic erosion through an accumulation of deleterious mutations. This Primer discu...

by Chris Condon, Andrea Galvez, Alexander Kramer, Landen Gozashti, Chris Vollmers, Manuel Ares Jr., Russell Corbett-Detig

Splicing deficiency may represent a critical yet underexplored form of genomic erosion in non-recombining regions. Across four phytoplankton species diverged ~333–639 million years ago, genes within U (female) and V (male) “UV” mating-type regions—non...

by Swathi Radha, Martina Arends, Georg Kislinger, Agata Rhomberg, Martina Schifferer, Minou Djannatian, Mikael Simons

Rapid information processing in complex organisms depends on myelin, which consists of a multilamellar membrane that tightly adheres to the axonal surface along the internode and at paranodal loops, where specialized adhesion proteins maintain axon-glial ...

by Jing Mo, Ding-Hao Zhuo, Min Gao, Ying Huang, Tao Cheng, Yang Dong, Yan-Yi Xing, Yun-Fei Li, Zi-Xin Jin, Xiang Liu, Guo-Qin Zhao, Hai-Rong Pu, Yu-Meng Liu, Li-Ping Shu, Peng-Fei Xu

Homeostasis is essential for hematopoiesis, and its dysregulation can lead to severe pathological conditions. Retinoic acid (RA) is a key regulator that exerts concentration-dependent effect...