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Lifespan.io's title: LEAF | Life Extension Advocacy Foundation

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Cellular Reprogramming: The Expert Roundup

Cellular reprogramming is one of the technologies most associated with longevity. The field was created in 2006, when Shinya Yamanaka showed that a cocktail of four transcription factors, commonly known as OSKM, can cause de-differentiation and massive rejuvenation of a cell, creating an iPSC (induced pluripotent stem cell). About a decade later, ...


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A Metabolic Shift Fuels Stem Cell Dysfunction

Researchers publishing in the Nature journal Cell Discovery have described how the age-related attenuation of a key metabolic axis causes human adipose-derived stem cells (hASCs) to lose functional capabilities.

Pinpoin...

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João Pedro de Magalhães on the Ethics of Longevity

João Pedro de Magalhães, professor at the University of Birmingham, is known as a prominent geroscientist who has been in the field forever, enriching it with top-tier research. He is also a skilled longevity advocate who has long taken interest in the ethics of longevity, first offering his perspective as far back as 2003. Prof. de Magalhães has ...


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Menopausal Hormone Therapy Does Not Increase Mortality

An analysis of over 800,000 women found no association between menopausal hormone therapy and increased mortality [1].

A controversial therapy

One of the first major changes that women undergo as they...


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Thermogeneration by White Fat Could Be Used to Treat Obesity

Scientists have discovered that, like brown fat, white fat has a mechanism that burns fuel to produce heat. This effect could potentially be used to create weight loss drugs [1].

Central heating

Ce...


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