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Lifespan.io's title: LEAF | Life Extension Advocacy Foundation

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Vast Majority of Alzheimer’s Cases Attributable to One Gene4 days ago

According to a new study, as many as 90% of Alzheimer’s cases can be attributed to “suboptimal” variants of the APOE gene. These results highlight the gene’s importance for Alzheimer’s prevention [1].

Three alleles of APOE

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Longevity Advocacy in 2025: The Expert Roundup4 days ago

The last installment in our end-of-year series of expert roundups might be the least flashy, but it is arguably no less important than the previous ones dedicated to longevity biotech and geroscience.

Public advocacy is a powerful lever. To quote Abraham Lincoln: “Public sentiment is everything. With it, nothing...

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The Geroprotective Potential of Hormone Replacement Therapy5 days ago

A recent review of literature investigated the risks and benefits of hormone replacement therapy. The authors point out that this approach could be used as a geroprotector to extend the healthspan of women. However, the risk-benefit r...

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Geroscience in 2025: The Expert Roundup7 days ago

2025 was a good year for geroscience, marked by rapid strides and critical milestones. Yet, the path wasn’t always smooth: progress in some areas lagged, research hit dead ends, and familiar bottlenecks persisted.

Against this backdrop, we asked five prominent geroscientists to share their perspectives on the hi...

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