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The objective of this study was to determine whether high-dose intravenous vitamin C improves a composite of 28-day mortality and persistent organ dysfunction in patients with severe burn injury.

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This international randomized clinical trial evaluates the efficacy of high-dose intravenous vitamin C in reducing 28-day mortality and persistent organ dysfunction (dependence on mechanical ventilation, kidney replacement therapy, or vasopressor/inotrope support at day 28) in patients with severe burn injury.

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In this issue of JAMA, Stoppe and colleagues present the results of an international randomized clinical trial that provides evidence that high-dose intravenous vitamin C does not improve outcomes in patients with large burns. The data from the VICTORY trial even suggest that use of vitamin C in patients with large burns might increase mortality. This well-designed study had str...

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The study evaluated whether an integrated multicomponent telehealth-based rehabilitation program across the intensive care unit, hospital ward, and postdischarge periods improves health-related quality of life at 90 days after hospital discharge in adults with acute hypoxemic respiratory failure requiring invasive mechanical ventilation.

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This randomized clinical trial assesses the effect of an integrated multicomponent telehealth-based rehabilitation intervention, compared with usual care, on health-related quality of life at 90 days after hospital discharge among adults with acute hypoxemic respiratory failure requiring invasive mechanical ventilation.

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