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Today I would like to introduce transformer based molecular generator named ‘ANNalog’ which can generate molecules like medchem. The URL of the article is below.
https://link.springer.com/article/10.1186/s13321-026-01186-6

Recently, generative AI can generate reasonable molecules under user defined conditions but it’s difficult to consider synthetic feasibility of generated molecules correctory. So building block beased approaches are developed for design novel drug like molecules. By using the approach, origin of designed molecules is building blocks and known reactions. It means synthetic fea...

Targeted Protein Degrader (TPD) is one of the attractive modality of recent drug discovery area. As most of readers know that First TPD, ER degrader gains FDA approval in this year.

TPD molecule induce PPI of POI and E3 ligase and degradation of POI. It is unique mechanism because chemical compounds can induce artificial degradation process. But the process is reall...