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Introduction to Computational Biology

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Message History

Antibodies vs small molecules [4 mins]
Antibody vs Small Molecule - Mechanisms & Pharmacokinetics - Drug Size Structure & Administration - Clinical Applications & Selection - Antibody vs Small Molecule Pros & Cons - Target Accessibility & Specificity - Innovations in Drug Development

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ICH S12: nonclinical biodistribution considerations for gene therapy products [27 mins]
Chapters of ICHS12 - Introduction (Objective and scope) - Definition of non-clinical (NC) biodistribution (BD) studies - Timing of BD studies - Design of BD studies - ICHS12: Specific considerations - Applications of BD studies

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Early evolution of animals: a paleontological perspective [42 mins]
Importance of fossils - Crown vs. stem groups -Holozoans - Ediacaran period - Bilaterians and sponges - Kimberella and Dickinsonia - Fossil embryos - Cryogenian and Tonian period

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Biomedicines: extraordinary opportunities amidst uncertain times [38 mins]
Evolution of the FDA - Eroom’s law - Blockbuster and me-too drugs - Eli Lilly as an innovator - Impact of mergers on biomedicine research - Industry consolidation and its impact - Impact of academia on biomedicines

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Applications of cell culture in drug development [4 mins]
Cell culture fundamentals - Cell culture requirements - Cell line types in research - Cell culture in drug development - Drug screening using cell culture - Limitations of cell culture models

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