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Small Study / Early Comparative Evidence
Ewing sarcoma before age 2 is exceptionally rare, leaving treatment decisions dependent on limited evidence and adaptation of protocols developed for older children. Investigators examined 17 French patients treated from 1988 through 2015 and compared their presentation, treatment, toxicity, and outcomes wit...
Small Study / Early Comparative Evidence
This prospective follow-up examined whether antibody blunting associated with Tdap vaccination during pregnancy persisted beyond infancy. Among children from an earlier Finnish clinical trial, maternal Tdap exposure was associated with lower pertussis toxin and diphtheria IgG concentrations at ages 3 and 4. ...
Legal / Ethical Complexity
Recent settlement agreements between the U.S. Department of Justice and six major hospital systems have resulted in the cessation of puberty-blocker, hormone, and surgical gender-affirming services for patients younger than 19 at participating institutions. The DOJ characterized the settlements as resolving investigations...
Observational Association Only Evidence
Researchers analyzed administrative claims for 2,031 patients aged 10 to 17 years who initiated GLP-1 receptor agonist therapy without a recently recorded nutritional deficiency. Within 12 months, 16.8% received at least one nutritional-deficiency or related-complication diag...
Mental Health / Behavioral Sensitivity
Parenting style has long been recognized as an important influence on child development, but many studies evaluate individual parenting behaviors rather than broader patterns of caregiving. Using data from the NIH Environmental Influences on Child Health Outcomes (ECHO) Program, investigators sought to identif...