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Investors of Merck & Co. (NYSE: MRK) and Moderna (Nasdaq: MRNA) were the most obvious—but not the only—beneficiaries when the companies announced what they said were the first-ever positive Phase III results for their mRNA-based cancer vaccine, the individualized neoantigen therapy (INT) intismeran autogene.
Merck and Moderna made ...
The human brain continues to develop for two decades. To study this prolonged process, researchers have traditionally relied on donated human brain tissue and animal models, both of which have limitations: donated tissue provides snapshots of brain development, and animal brains differ from the human brain in cell-type composition and timing of development.
Despite the...
A growing view among geneticists holds that nearly every gene active in the relevant tissue plays some part in a disease, but the vast majority act only indirectly and from a distance, nudging a much smaller set of “central” genes that sit at the heart of the disease. Those central genes are the ones that directly drive the biology and therefore are the ones most worth target...
During brain development, distinct areas emerge that take on different jobs including movement, vision, memory, and language. At this stage of development, chemical signals help tell developing cells where they are, contributing to differences between areas at the front and the back of the cerebral cortex. This process, dubbed arealization by scientists, is believed to underp...
In recent years, the artificial intelligence (AI) conversation has been dominated by increasingly capable large language models. Every few months, models improve on mathematical reasoning and coding benchmarks, while inference costs drop. Since 2025, programmers have become more familiar with Claude Code and OpenAI Codex, autonomous software engineering agents running locally...