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Website title: Latest research | eLife

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Replacing the immune system of the brain
A new method enables engineered immune progenitor cells to replace microglia in mice and reveals how a genetic mutation can lead to inflammation in the brain.

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Large-scale identification of plasma membrane repair proteins revealed spatiotemporal cellular responses to plasma m...
Damage to the plasma membrane (PM) is common in all types of cells. PM repair processes, including exocytosis and endocytosis, are not mutually exclusive; rather, they collaborate to repair the wound. However, the temporal coordination between the repair processes remains poorly understood. Here, by large-scale identification and live-cell imaging of PM repair proteins, we analy...

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Movie reconstruction from mouse visual cortex activity
The ability to reconstruct images represented by the brain has the potential to give us an intuitive understanding of what the brain sees. Reconstruction of visual input from human fMRI data has garnered significant attention in recent years. Comparatively less focus has been directed towards vision reconstruction from single-cell recordings, despite its potential to provide a m...

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Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechani...
It is known that stress powerfully alters pain, but its underlying mechanisms remain elusive. Here, we identified a circuit, locus coeruleus descending noradrenergic neurons projecting to the spinal dorsal horn (LC→SDH-NA neurons), that is activated by acute exposure to restraint stress and is required for stress-induced mechanical pain hypersensitivity in mice. Interestingly, t...

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Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bac...
Microbial competition for trace metals shapes their communities and interactions with humans and plants. Many bacteria scavenge trace metals with metallophores, small molecules that chelate environmental metal ions. Metallophore production may be predicted by genome mining, where genomes are scanned for homologs of known biosynthetic gene clusters (BGCs). However, accurately det...

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