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Website title: Latest research | eLife

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Trained immunity and immune priming in plants and invertebrates

Immune memory has long been thought to be restricted to the adaptive immune system of vertebrates. However, several lines of evidence have changed our understanding of immune memory and have shattered the strict separation between innate and adaptive immunity. In vertebrates, a form of innate immunity that is called ‘trained immunity’ has been intensively studied for over a deca...

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Extracellular matrices regulate extravasation journey of leukocytes and inflammatory tissue fate

Leukocyte extravasation across the blood endothelium to inflamed tissues is a crucial defence mechanism against invading pathogens. After the elimination of the pathogen in the tissue, inflammation needs to be resolved back to steady state. This cascade comprises at least three stages: transmigration through the endothelium and the underlying basement membrane, intra-tissue leuk...

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Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

Small-conductance calcium-activated potassium channel 2 (SK2) serves a variety of biological functions by coupling intracellular calcium dynamics with membrane potential. SK2 modulators are in development for the treatment of neurological and cardiovascular diseases, though the mechanisms of pharmacological modulation remain incompletely understood. We determined structures of a...

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Crossover in aromatic amino acid interaction strength between tyrosine and phenylalanine in biomolecular condensates

Biomolecular condensates often form through the self-assembly of disordered proteins with low-complexity sequences. In these polypeptides, the aromatic amino acids phenylalanine and tyrosine act as key ‘sticker’ residues, driving the cohesion of dense phases. Recent studies on condensates suggest a hierarchy in sticker strength, with tyrosine being more adhesive than phenylalani...

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Ptbp1 is not required for retinal neurogenesis and cell fate specification

The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes neurogenesis, recent genetic studies have failed to replicate glia-to-neuron conversion following Ptbp1 loss of functi...

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