Hey Cam, I hope the naltrexone helps out a lot.

One other extremely-well-studied supplement* to consider is creatine monohydrate. It helps increase the efficiency of the krebs cycle within mitochondria, effectively creating a boost in intracellular energy. While most often used by bodybuilders or MS patients for increased muscle strength, folks are also seeing some interesting and subtle nootropic effects of this supplement (at least being neuroprotective). Many people have reported it has helped with focus, mood, and cognition in general; makes sense as mitochondria are in all of our cells, so making our cells work more efficiently will have wide ranging impact.

* Most supplements are a scam and any highly unregulated industry needs serious consideration before dabbling. If you're in the US, I would look for NSF certified supps.

Just in case you're worried I'm talking out of my ass:

- https://pmc.ncbi.nlm.nih.gov/articles/PMC10630839/
- https://pubmed.ncbi.nlm.nih.gov/38684388/
- https://clinicaltrials.gov/study/NCT06992414
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10394531/ (study showing decreased levels of creatine in patients with long covid, so potential evidence that supplementation might be required)

Creatine monohydrate is one of the cheapest supplements around. Frankly, given how well its tolerated by gen pop, I think most folks should consider taking it in their mid 30s.. forever. I'd recommend a micronized version for the extra couple of bucks, waaaaaaay easier to get down or mix into a smoothie.

I hope this info helps!! At least something to consider.

Statistics: Posted by thef0x — Mon Jun 15, 2026 10:53 am

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