Chemical Forums

https://www.sciencedirect.com/science/article/pii/S1570023211003321?via%3Dihub#fig0015
Hi Borek,

I believe that you are correct. nbsp The question then becomes under what conditions is it reasonable to assume a linear standard...

Isn'#039t using ratio of signals equivalent to assumption standard curve is just linear and goes through 0

I am reading a paper right now which used the IDMS method to quantify two metabolically related amino acids from a biological sample. nbsp Each of their standards was a d5-analyte. nbsp They indicated that there was a negligible amount of the natural amino acids (which I take to mean amino acids with a natural abundance of isotopes). nbsp It sounds as if they took the ratio of s...

Our compound has a tertiary-butyl ester and Boc group, as well as a vinyl ketone. nbsp We deprotected similar compounds using TFA/DCM, and until now have not had a problem. nbsp Our third attempt produced a mixture that may contain some product. nbsp A more experienced colleague suggested that cyclization of some sort is possible, but we don'#039t yet have evidence of t...

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