Chacko's Critical Care Blogspot

Background  Acute pulmonary embolism encompasses a broad spectrum of clinical severity, ranging from an incidental finding to a life-threatening condition with a substantial risk of mortality (1). In particular, those with intermediate-to-high-risk pulmonary embolism may deteriorate hemodynamically without warning despite therapeutic anticoagulation. Intravenous thrombolysis may...

Neyra JA, Legrand M, Tidswell MA, Al-Khafaji A, Galphin C, Rains R, et al. Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial. Lancet Respir Med. 2026 May;14(5):443–52. Introduction  High endotoxin activity has been associated with organ dysfunction and mortality in sepsis (1). Historically, ...