Biomedical Research and Therapy

Background: Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality globally. The therapeutic efficacy of doxorubicin (DOX) in HCC is frequently compromised by chemoresistance mediated by adaptive cel...

Background: Interleukin-6 (IL-6) is a pivotal pro-inflammatory cytokine linked to the pathophysiology of major depressive disorder (MDD). Methyl-CpG binding protein 2 (MECP2) is an essential epigenetic reader that regulates chromatin architec...

Background: The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a central mediator of cardiometabolic inflammation. Its activation promotes the maturation and release of interleukin-1β (IL-1β) and interleukin-18 (IL-18), accelerating vascular...

Background: Heart failure (HF) is a complex clinical syndrome characterized by sustained inflammatory activation, oxidative stress, and extensive alterations in gene regulation. Leukemia inhibitory factor (LIF), a pleiotropic cytokine belonging to the interleukin-6 (IL-6) su...

Background: Premature ovarian failure (POF) is a debilitating complication of cytotoxic chemotherapy, characterized by the accelerated depletion of the ovarian primordial follicle reserve and the consequent loss of endocrine an...