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Biomedical Research and Therapy

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Advances in research on ferroptosis in jaw bone augmentation

Ferroptosis, an iron-dependent form of regulated cell death (RCD) driven by lipid peroxidation, has emerged as a critical regulatory mechanism in jawbone augmentation, which addresses a major barrier to successful dental implants: insufficient jawbone volume. This review summarizes the molecular basis of ferroptosis and jaw-specific features that regulate it (high mitochondri...


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Mesenchymal Stem Cell Therapy for Thin Endometrium: Mechanisms, Delivery Strategies, and Clinical Outcomes: A System...

Thin endometrium constitutes a significant cause of infertility that demonstrates an inadequate response to conventional treatments, prompting the investigation of mesenchymal stem cell (MSC)-based regenerative therapies as alternative interventions. This systematic review, conducted in accordance with PRISMA guidelines, evaluated primary research from January 2020 to January...


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Non-Enzymatic Isolation of Stromal Vascular Fraction (SVF) And Adipose-Derived Stem Cells (ADSCs): A Systematic Meth...

Non-enzymatic isolation of the stromal vascular fraction (SVF) has gained increasing clinical interest due to the regulatory, safety, and logistical constraints associated with enzymatic digestion. However, reported outcomes following their use remain heterogeneous, and direct quantitative comparisons are limited. This systematic review and exploratory meta-analysis aimed to ...


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In silico identification of highly conserved cytotoxic T-lymphocyte (CTL) epitopes from Streptococcus pyogenes exoen...

Background: Streptococcus pyogenes represents a major global health concern attributable to its extensive repertoire of virulence factors, which contribute to severe diseases, most notably streptococcal pharyngitis. To facilitate the development of a safer, more targeted vaccine, this study employed a comprehensive in silico immunoinformatic...


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A Comparative Analysis of the Effects of Oral Gabapentin and Intravenous Dexamethasone on Postoperative Pain Followi...

Background: Optimizing post-operative pain management is paramount for patient recovery and satisfaction. Non-opioid analgesic agents, such as gabapentin and dexamethasone, are frequently utilized as adjunctive therapies to attenuate opioid consumption and mitigate associated adverse effects. This study sought to compare the analgesic efficacy of oral gabapen...


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