Biomedical Research and Therapy

Osteosarcoma is a highly aggressive primary bone malignancy characterized by a poor prognosis due to treatment-related toxicity and chemoresistance. This clinical challenge has spurred growing interest in natural adjuncts, particularly plant-derived therapeutic agents. Azolla pinnata, an aquatic fern, is recogni...

Background: Demyelinating diseases of the central nervous system (CNS), such as multiple sclerosis (MS), are characterized by the progressive loss of myelin, leading to neurological deficits. Current therapies demonstrate limited efficacy in promoting remyelination. This r...

Aromatase, an enzyme responsible for converting androgens to estrogens, plays a crucial role in maintaining physiological homeostasis. It is also an essential factor in estrogen-dependent carcinogenesis. For many years, aromatase inhibitors (AIs), such as letrozole and vorozole, have been applied mainly in the treatment of breast cancer. Their utilization in managing breast a...

Abstract: Psoriasis is a chronic immune-mediated skin disorder driven by dysregulation of the IL-23/IL-17 axis. Human umbilical cord–derived mesenchymal stem cells (hUC-MSCs) possess immunomodulatory and anti-inflammatory properties, making them a potential therapeutic candidate for psoriasis treatment. In this study, we evaluated the therapeutic effects of l...

Background: Cellular immunotherapies utilizing γδT cells hold immense promise for breast cancer as an MHC-independent approach; however, their clinical efficacy is profoundly dictated by the tumor microenvironment and systemic metabolic contexts. While cancer patients routinely consume widely available p...