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Bariatric News

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Rani Therapeutics initiates phase 1 study of RT-114 RaniPill

Rani Therapeutics has initiated a Phase 1 clinical trial to evaluate the safety, tolerability, bioavailability and pharmacokinetics and pharmacodynamics of single and multiple doses of RT-114, an orally administered RaniPill capsule containing a GLP-1/GLP-2 dual agonist, PG-102, for the treatment of obesity. RaniPill PG-102 is a fc-fusion protein conjugated GLP-1/GLP-2 dual agon...


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Stopping weight loss drugs linked to weight regain and reversal of beneficial heart health markers

Stopping weight loss drugs is followed by weight regain and reversal of beneficial effects on heart and metabolic health markers such as high cholesterol and high blood pressure, according to a study by University of Oxford researchers. The study shows that the average rate of weight regain is 0.4kg/month after stopping treatment, with weight and risk markers for diabetes and he...


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Metabolic BMI model uses AI to reveal hidden metabolic disorders

Researchers at Leipzig University and the University of Gothenburg have developed a novel approach to assessing an individual's risk of metabolic diseases such as diabetes or fatty liver disease more precisely. Instead of relying solely on the widely used body mass index (BMI), the team developed an AI-based computational model using metabolic measurements. Systems view of metab...


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Lack of support for people on weight loss drugs leaves them vulnerable to nutritional deficiencies

People prescribed the new generation of weight loss drugs may not receive sufficient nutritional guidance to support safe and sustainable weight loss, leaving them vulnerable to nutritional deficiencies and muscle loss, according to University College London (UCL) and University of Cambridge researchers. The research led by Dr Marie Spreckley from the University of Cambridge, fo...


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One in ten British adults used or interested in GLP-1 medications for weight loss

In 2025, approximately 4.9 million British adults — almost one in ten — are estimated to have recently used, or expressed interest in using, glucagon-like peptide-1 (GLP-1) or dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist medications to support weight loss. The GLP-1 and GLP-1/GIP medications liraglutide, semaglutide and tirzepatide are licensed ...


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