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Website title: Allergy Notes, Evidence-based Information by Board-certified Physicians
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Jasper Therapeutics announced promising updated clinical data on January 8, 2026, for briquilimab, a monoclonal antibody targeting KIT (CD117) to deplete mast cells and treat mast cell-driven conditions like chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU).
Key highlights include rapid and durable symptom relief, measured by the Urticaria Acti...
A first-in-class, once-daily oral STAT6 degrader is being studies for eosinophilic asthma.
KT-621 targets STAT6, the key transcription factor driving IL-4/IL-13-mediated Type 2 inflammation, aiming to deliver biologics-like efficacy in an oral form.
The primary endpoint is change from baseline in FEV1.
This trial runs alongside the ongoing BROADEN2 Phase 2b ...
Early Phase 2b data (REZOLVE-AD trial, NCT06136741) support rezpegaldesleukin (rezpeg), a first-in-class IL-2 agonist that selectively expands regulatory T cells to restore immune balance.
In this randomized, double-blind, placebo-controlled study of adults with moderate-to-severe atopic dermatitis (AD), the highest dose (24 µg/kg every 2 weeks for 16 weeks) delivered s...
The American College of Chest Physicians (CHEST) published a key clinical practice guideline in CHEST journal titled "Biologic Management in Severe Asthma for Adults: An American College of Chest Physicians Clinical Practice Guideline."
Severe asthma affects 5–10% of asthma patients but drives nearly half of asthma costs due to exacerbations and high corticosteroid use....
For decades, leukotrienes - molecules derived from white blood cells - were blamed as one of the main causes of asthma symptoms like airway constriction and wheezing. Drugs like montelukast (Singulair) target their receptors based on this view.
New research from Case Western Reserve University (led by chemist Robert Salomon, PhD) challenges that. Published in the Journa...