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Acta Pharmacologica Sinica

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Editorial Expression of Concern to: Acta Pharmacologica Sinica https://doi.org/10.1038/aps.2009.124, published online 24 August 2009.


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Chemoresistance is a major factor contributing to the poor prognosis of osteosarcoma. Increasing evidence underscores the pivotal role of enhanced tumor stemness in driving drug resistance. In this study we investigated the molecular mechanisms underlying the chemoresistance and stemness in osteosarcoma. Two cisplatin-resistant osteosarcoma cell line models (U2OS-DDPr and 143...


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Mitochondrial DNA (mtDNA) damage and accumulation activate the cGAS-STING DNA-sensing pathway, which promotes immune clearance of tumor cells. Maintenance of the cytosolic level of mtDNA is key to sustain immune activation. T cell malignancies (T-CMs) are a general name of diseases with abnormal clonal proliferation of T lymphocytes at various stages. Immunotherapy of T-CMs i...


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Cancer stem cells (CSCs) play a key role in the progression of colorectal cancer (CRC). The high heterogeneity of CSCs has hindered the clinical application of CSC-targeting therapies. Tetracyclines are drugs with therapeutic potentials beyond their antibiotic activity. We previously demonstrated the efficacy of tigecycline, a third-generation tetracycline, against a model of...


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RNA m6A methylation, as the most prevalent modification in mRNA, is a dynamic and reversible process primarily regulated by m6A methyltransferases (“writers”), m6A demethylases (“erasers”), and m6A recognition proteins (“readers”). It has been shown that N6-methyladenosine (m6A) plays a pivotal role in hepatocellular carcinoma (HCC). In this study we investigated the contribu...


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