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The amiloride-sensitive sodium channel (ENaC) is a trimeric complex (αβγ) critical for epithelial fluid and electrolyte homeostasis — a focus in cystic fibrosis, hypertension, and renal salt handling[reference:109]. Among its s...
Sestrin-3 (SESN3) is a hypoxia-inducible, stress-gated metabolic modulator that answers to HIF-1α rather than p53, positioning itself at the intersection of nutrient stress and oxygen sensing[reference:78]. Unlike its better-known sibling SESN2, ...
Secreted Frizzled-Related Protein 2 (SFRP2) is a soluble antagonist of Wnt ligands that modulates cell proliferation, differentiation, and tissue remodeling[reference:48]. Unlike the transmembrane Frizzled receptors that receive the Wnt signal, SFRP2 belong...
Sialic acid-binding Ig-like lectin 8 (SIGLEC8) is a sialic acid–recognizing inhibitory receptor expressed almost exclusively on eosinophils, basophils, mast cells, and group 2 innate lymphoid cells (ILC2s) — the very cellular axis driving severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), eosinoph...
SLC16A3 (Monocarboxylate Transporter 4, MCT4) mediates the efflux of lactate and ketone bodies in glycolytic tissues — a process central to the Warburg effect in cancer, exercise-induced metabolic adaptation in muscle, and neurodegenerative disease p...