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Website title: 2 Minute Medicine | Concise. Curated. Medical News.

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Replacing sedentary time with physical activity may lower risk of all-cause mortality

1. In this prospective cohort, individuals with greater periods of sedentary time have increased risks of all-cause mortality and mortality from cancer, cardiovascular disease, and respiratory disease.  2. Replacing sedentary behaviour with physical activity substantially lowers these risks.  Evidence Rating Level: 1 (Excellent)  Sedentary behaviour (SB), defin...


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Metformin and ursodeoxycholic acid do not improve long COVID recovery

1. In this randomized controlled trial, neither metformin nor ursodeoxycholic acid improved recovery from long COVID compared with placebo in adults. 2. Participants who recovered from long COVID showed reductions in multiple cytokine levels, while those who did not recover showed no meaningful changes. Evidence Rating Level: 1 (Excellent) Study Rundown: Metformin has immunom...


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Breast cancer screening with MRI provides modest benefit for high-risk women

1. For women at higher-than-average risk, adding supplemental MRI to DBT provided only modest additional benefit, resulting in a similar harm-benefit balance compared with DBT alone. 2. Across all risk levels, biennial DBT starting at age 50 was the most cost-effective strategy. Evidence Rating Level: 2 (Good)  Study Rundown: A substantial proportion of women undergoing ...


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2 Minute Medicine Rewind March 2, 2026

Extended follow-up of invasive cervical cancer risk after quadrivalent HPV vaccination: nationwide, register based study 1. In this cohort study, the quadrivalent human papillomavirus (HPV) vaccine provides strong, long-lasting protection against invasive cervical cancer, with the greatest benefit if vaccination occurs before age 17.  Evidence Rating Level: 2 (Good) ...


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Adults with attention-deficit/hyperactivity disorder are at higher risk of poor long-term adherence to antihypertens...

1. Adults with attention-deficit/hyperactivity disorder are more likely to discontinue antihypertensive therapy and demonstrate poor long-term adherence. 2. Use of attention-deficit/hyperactivity disorder medication is associated with improved adherence to antihypertensive treatment among affected individuals Evidence Rating Level: 2 (Good)  This multinational cohort stu...


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