2minutemedicine

1. The antithrombotic agents aspirin, clopidogrel, and rivaroxaban were non-inferior to metoprolol for responder rate in participants with patent foramen ovale and migraine. Evidence Rating Level: 1 (Excellent) Patent foramen ovale (PFO) has been associated with migraine and has been suggested to involve a microembolic mechanism. Antithrombotic treatment has been proposed for...

1. Active surveillance was cost-effective over 5 years compared with standard surgery in patients with esophageal cancer and complete clinical response after neoadjuvant chemoradiotherapy. Evidence Rating Level: 1 (Excellent) Active surveillance for patients with esophageal cancer and a complete clinical response (CCR) after neoadjuvant chemoradiotherapy (nCRT) is noninferior...

1. Intraarterial dexamethasone was associated with greater pain relief after uterine fibroid embolization compared with placebo.  Evidence Rating Level: 1 (Excellent) Uterine fibroid embolization (UFE) is a minimally invasive treatment for symptomatic uterine fibroids, which are most common tumor of the female reproductive tract. However, a major limitation of UFE is acute po...

1. Hematologic inflammatory indices in emergency department patients with COVID-19 showed an age-dependent prognostic performance for 30-day mortality, with systemic immune-inflammation index showing good discriminatory performance in patients <65 years and poorer performance in patients >65 years. Evidence Rating Level: 2 (Good) Hematologic markers derived from the com...

1. Younger age (<59.6 years) and systemic metastases (>1) were independent predictors of survival among patients with choroidal metastases. Evidence Rating Level: 2 (Good) Around 1–2% of all cancer patients develop intraocular metastases, with the choroid representing the primary site of metastatic involvement (90%). It is unclear how age and primary tumor type impact s...